Opportunity: NOVEL IN SITU IMAGING AND MEASUREMENT TECHNOLOGIES

Description 

The Office of Biological and Environmental Research (BER) supports fundamental research to advance a predictive understanding of complex biological and environmental systems relevant to DOE’s energy and environmental missions. Starting with the genetic potential encoded by organisms’ genomes, BER supported scientists seek to define the principles that guide the translation of the genetic code into functional proteins, as well as understanding the metabolic and regulatory networks underlying the systems biology of plants and microbes. Concurrent with this research is a need for enabling technologies to place the understanding of gene expression, regulation, and function into the spatiotemporal context of the whole cell environment. The traditional approach to understanding cellular metabolism has been to define specific biochemical steps and identify the substrates, enzymes, and regulatory molecules that carry out those chemical reactions. However, these experiments have been largely inferential, mostly conducted either by examining isolated enzymes or pathways of limited complexity, and extrapolating to higher scale function or else by taking aggregate measurements of cellular metabolism and inferring network relationships. A major challenge is to understand how these pathways are interconnected and controlled within topological constraints at the subcellular scale within living systems, with different biological macromolecules existing in spatially defined or membrane-bounded regions within the cell. Although a substantial amount of molecular level understanding of the biological macromolecules that mediate internal cellular processes has been achieved, new capabilities are needed to examine these processes as they occur in situ. Integrating molecular scale genetic and biochemical information with cellular spatial and temporal dynamics is critical to gaining a systems level understanding of the continual reorganization and remodeling of cellular processes. Thes

Overview 
Reference number: DE-FOA-0001192
Issue date: 09/10/2014
Response due: 12/18/2014 11:59 PM US/Eastern

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Agency: DOE

Contracting office:

Office of Science - Chicago
U.S. Department of Energy
Office of Acquisition & Assistance
9800 South Cass Avenue
Argonne, IL 60439


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